Is Zofran safe to use during pregnancy? This is a question that has been raised after a recent study was released in the publication, The Toronto Star. The study found a correlation between those who took the morning sickness drug and had children born with birth defects.
Congenital Heart Defects
The studies in The Toronto Star indicated a correlation to the use of Zofran during pregnancy and congenital heart defects. Congenital heart defects include Ventricular Septal Defect (VSD), Atrial Septal Defect (ASD), among others.
Cleft Palate and Cleft Lip
Cleft palate and cleft lip are both deformities that can be caused by Zofran. Cleft lip and palate occur when the tissues in the face and mouth do not form properly. The tissues are fused together in the second and third months of pregnancy. In babies with a cleft palate of cleft lip, the fusion doesn’t occur. Many difficulties can be found for children who have a cleft lip or palate, such as feeding. Ear infections and hearing loss are also more susceptible to children with then malformations.
Studies suggest Zofran could be linked to an increase risk of congenital kidney defects and malformations. In some, one or both kidneys will fail to fully develop. Other malformations will cause a blockage, backing up urine in the kidney. This condition is called hydronephrosis and will cause the kidney to become enlarged. Another common defect is reflux, where a valve other the ureter does not work properly, allowing urine to back up in the kidneys.